1-(3,4-Dichlorophenyl)-3-(1,3-thiazol-2-yl)thiourea is a thiourea derivative synthesized from 1,3-thiazole. The 1,3-thiazoles are an important group of compounds due to their wide range of applications in biopharma. The thioureas have been described as the most useful class of agents, with a large number of activities including antiviral, antibacterial, and lipoprotein (HDL)-elevating properties. The compound is active against Gram-positive cocci and Mycobacteria. It has been found to inhibit biofilm formation in wild type and methicillin-resistant strains of Staphylococcus epidermidis.
We also offer:
- 1-(3-Chloro-4-fluorophenyl)-3-(1,3-thiazol-2-yl)thiourea (C216)
| Mechanism of Action | The electron-withdrawing halogen atom, especially at the 3rd position of the phenyl group is significantly important for the antimicrobial activity. |
| Spectrum | 1-(3,4-Dichlorophenyl)-3-(1,3-thiazol-2-yl)thiourea is active against Gram-positive cocci including Staphylococcus species including methicillin-resistant S. epidermidis. It is also effective for Mycobacteria, including M. tuberculosis. It also has cytotoxicity and antiviral activity on a large set of DNA and RNA viruses, including HIV type 1 (HIV-1). |
| Microbiology Applications | 1-(3,4-Dichlorophenyl)-3-(1,3-thiazol-2-yl)thiourea has in vitro tuberculostatic activity against M. tuberculosis. The compound also has an inhibitory effect for biofilm formation by standard and selected hospital methicillin-resistant strains of S. epidermidis (MRSE). |
| Molecular Formula | C10H7CL2N3S2 |
| References |
Stefanska J et al (2015) Antimicrobial and anti-biofilm activity of thiourea derivatives incorporating a 2-Aminothiazole scaffold. Chem. Pharm. Bull. 63(3):225-236 PMID 25757494 |
