SKU: D076



    1-(3,4-Dichlorophenyl)-3-(1,3-thiazol-2-yl)thiourea is a thiourea derivative synthesized from 1,3-thiazole. The 1,3-thiazoles are an important group of compounds due to their wide range of applications in biopharma.  The thioureas have been described as the most useful class of agents, with a large number of activities including antiviral, antibacterial, and lipoprotein (HDL)-elevating properties.  The compound is active against Gram-positive cocci and Mycobacteria.  It has been found to inhibit biofilm formation in wild type and methicillin-resistant strains of Staphylococcus epidermidis.

    We also offer:

    • 1-(3-Chloro-4-fluorophenyl)-3-(1,3-thiazol-2-yl)thiourea (C216)
    Mechanism of Action The electron-withdrawing halogen atom, especially at the 3rd position of the phenyl group is significantly important for the antimicrobial activity.
    Spectrum 1-(3,4-Dichlorophenyl)-3-(1,3-thiazol-2-yl)thiourea is active against Gram-positive cocci including Staphylococcus species including methicillin-resistant S. epidermidis.  It is also effective for Mycobacteria, including M. tuberculosis.  It also has cytotoxicity and antiviral activity on a large set of DNA and RNA viruses, including HIV type 1 (HIV-1).
    Microbiology Applications 1-(3,4-Dichlorophenyl)-3-(1,3-thiazol-2-yl)thiourea has in vitro tuberculostatic activity against M. tuberculosis.   The compound also has an inhibitory effect for biofilm formation by standard and selected hospital methicillin-resistant strains of S. epidermidis (MRSE).
    Molecular Formula C10H7CL2N3S2

    Stefanska J et al (2015)  Antimicrobial and anti-biofilm activity of thiourea derivatives incorporating a 2-Aminothiazole scaffold.  Chem. Pharm. Bull. 63(3):225-236  PMID 25757494