1-(3-Chloro-4-fluorophenyl)-3-(1,3-thiazol-2-yl)thiourea is a thiourea derivative (specifically the 3-chloro-4-fluorophenyl-substituted derivative) synthesized from 1,3-thiazole. The 1,3-thiazoles are an important group of compounds due to their wide range of applications in biopharma. The thioureas have been described as the most useful class of agents, with a large number of activities including antiviral, antibacterial, and lipoprotein (HDL)-elevating properties. The compound is active against Gram-positive cocci and Mycobacteria. It has been found to inhibit biofilm formation in wild-type and methicillin-resistant strains of Staphylococcus epidermidis.
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- 1-(3,4-Dichlorophenyl)-3-(1,3-thiazol-2-yl)thiourea (D076)
|Mechanism of Action||The halogen atom is especially important for its antimicrobial activity. It was found that electron-withdrawing substituents like chlorine and fluorine were the most potent antibacterial agents against Gram-positive cocci. Disubstituted compounds like this are more potent than monosubstituted compounds because the first group produce stronger electronegativity effect.|
|Spectrum||The compound is active against Gram-positive cocci and Mycobacteria. It has cyctotoxic and antiviral activity on a large set of DNA and RNA viruses including HIV (HIV-1). It can inhibit biofilm formation in wild-type and methicillin-resistant strains of S. epidermidis.|
|Microbiology Applications||The compound has in vitro tuberculostatic activity against M. tuberculosis. It can inhibit biofilm formation by standard and selected hospital methicillin-resistant strains of S. epidermidis (MRSE).|
Stefanska J et al (2015) Antimicrobial and anti-biofilm activity of thiourea derivatives incorporating a 2-aminothiazole scaffold. Chem. Pharm. Bull. 63(3):225-236 PMID 25757494