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    epi-Ivermectin B1a is a base-catalysed intermediate in the decomposition of ivermectin. epi-Ivermectin B1a is formed by epimerisation at the 2-position which ultimately rearranges irreversibly to the isomeric alkene analogue, Δ2-ivermectin B1a. Despite the importance of ivermectin as an anthelmintic in animal health, there are no published reports of the biological activity or the levels of epi-ivermectin B1a in animals or the environment.

    epi-Ivermectin B1a is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    ReferencesBase-catalyzed isomerization of avermectins. Pivnichny J.V. et al. J. Agric. Food Chem. 1988, 36, 826.

    Direct determination of avermectins in plasma at nanogram levels by High-Performance Liquid Chromatography. Pivnichny J.V. et al. J. Pharm. Sci. 1980, 72, 1447.