SKU: M002  / 
    CAS Number: 119478-56-7

    Meropenem, USP

    $167.25

    Meropenem is a β-lactam antibiotic in the carbapenem class, and targets the bacterial cell wall.   It has found utility against extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae  that are resistant to many first line β-lactam antibiotics and certain cephalosporins.  Meropenem is sparingly soluble in aqueous solution.

    We also offer:

    • Meropenem with sodium carbonate (M028) 
    Mechanism of Actionβ-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many carbapenems, meropenem is highly resistant to the degradative effects of β-lactamases.
    SpectrumMeropenem is a broad-spectrum antibiotic targeting a wide range of bacteria especially those causing meningitis.
    Impurity ProfileChromotographic Purity:
    Any two major impurities: Not more than 0.3%
    Single impurity: Not more than 0.1%
    Total impurities: Not more than 0.3%
    Microbiology ApplicationsMeropenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Meropenem has also shown high potency against high-resistant superbug strains.Medical microbiologists use AST results to recommend antibiotic treatment options.  Representative MIC values include:
    • Staphylococcus epidermidis 0.06 µg/mL - 16 µg/mL
    • Neisseria meningitis 0.002 µg/mL – 0.03 µg/mL
    • For a complete list of Meropenem MIC values, click here.

    Media Supplements

    Meropenem can be used as a selective agent in several types of isolation media:

    VRE Medium - VRE Selective Supplement

    Plant Biology ApplicationsMeropenem can be used to suppress the overgrowth of Agrobacterium in tobacco, tomato, and rice transformation, with 25 mg/L suppressing outgrowth (Ogawa and Mii , 2007).

    Meropenem suppressed growth of Agrobacterium during transformation of Phalaenopsis at 5 mg/L and had no phytotoxic effect on the cells themselves (Sjahril and Mii, 2005).
    Molecular FormulaC17H25N3O5S • 3H2O
    References

    Guzmán F(2008)  Beta lactams antibiotics (penicillins and cephalosporins) mechanism of action. Med. Pharmacol.  Pharmacology Corner, 29 Nov. 2008

    Ogawa Ya and Mii M (2007)  Meropenem and moxalactam: Novel B-lactam antibiotics for efficient Agrobacterium-mediated transformation. 172(3):564-572

    Pitout JD, Sanders CC, Sanders WE (1997)  Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 103:51

    Sjahril R and Masahiro Mii M (2006) High-efficiency Agrobacterium-mediated transformation of Phalaenopsis using meropenem, a novel antibiotic to eliminate Agrobacterium. J. Hort. Sci and Biotechnol 8(3):458-464

    Yang Y, Bhachech N and Bush K (1995)  Biochemical comparison of imipenem, meropenem and biapenem: Permeability, binding to penicillin-binding proteins, and stability to hydrolysis by β-lactamases. J. Antimicrob.  Chemother. 35(1):75-84

    MICBacteroides caccae| 0.06 - 8|| Bacteroides capillosus | 0.06 - 0.5|| Bacteroides distasonis| 0.06 - 4|| Bacteroides fragilis| 0.008 - 77|| Bacteroides ovatus| 0.06 - 4|| Bacteroides splanchnicus | 0.06 - 0.5|| Bacteroides stercoris| 0.06 - 4|| Bacteroides thetaiotaomicron| 0.06 - 4|| Bacteroides uniformis| 0.06 - 8|| Bacteroides ureolyticus| 0.06 - 0.5|| Bacteroides vulgatus| ≤0.03 - 8|| Bacteroides xylanisolvens | ≥0.25|| Bifidobacterium spp.| 0.03 - 2|| Bilophila wadsworthia| ≥0.06 - 0.12|| Bordetella pertussis | 0.125 - 0.25|| Borrelia burgdorferi S.L.| 0.015 - 0.5|| Burkholderia cepacia| 0.25 - 16|| Burkholderia spp.| 0.25 - 8|| Campylobacter fetus| ≤0.06 - 0.5|| Campylobacter gracilis| 0.06 - 0.25|| Citrobacter freundii| 0.016 - 32|| Citrobacter koseri| ≤0.06|| Citrobacter koseri (Europe)| 0.13|| Citrobacter koseri (North America)| <0.06|| Clostridium bifermentans| ≥0.125|| Clostridium butyricum| ≤0.03 - 1|| Clostridium cadaveris| ≥0.03|| Clostridium clostridioforme| ≤0.03 - 1|| Clostridium difficile| 1 - 4|| Clostridium innocuum| 1 - 2|| Clostridium paraputrificum| ≥0.25|| Clostridium perfringens| ≤0.004 - 0.06|| Clostridium ramosum| ≤0.03 - 2|| Clostridium septicum| ≤0.03 - 1|| Clostridium sordellii| ≥0.06|| Clostridium sporogenes| ≤0.03 - 1|| Clostridium spp.| ≤0.004 - 4|| Enterobacter aerogenes| ≤0.008 - 16|| Enterobacter cloacae| ≤0.008 - 16|| Enterobacteriaceae| 0.15 - 4|| Enterococci| 0.004 - 128|| Enterococcus faecalis| 1 - 64|| Enterococcus faecium| 1 - >128|| Enterococcus gallinarum| ≥15.6|| Escherichia coli| ≤0.007 - >32|| Eubacterium lentum| 0.06 - 8|| Eubacterium limosum| 0.06 - 0.5|| Eubacterium spp.| 0.008 - 0.25|| Finegoldia magna| 0.06 - 0.25|| Fusobacterium mortiferum| ≤0.03 - 8|| Fusobacterium necrophorum| ≤0.016 - 8|| Fusobacterium nucleatum| 0.008 - 8|| Fusobacterium spp.| ≤0.004 - 8|| Fusobacterium varium| ≤0.03 - 8|| Gram-Positive Anaerobic Cocci| 0.03 - 0.12|| Haemolytic streptococci| 0.002 - 0.06|| Haemophilus influenzae| 0.016 - 1|| Haemophilus spp.| 0.015 - 0.25|| Klebsiella aerogenes (1522E)| ≥0.05|| Klebsiella pneumonia| 0.008 - >32|| Lactobacillus catenaforme| 0.06 - 0.5|| Lactobacillus jensenii| 0.06 - 0.5|| Lactobacillus spp.| 0.06 - 4.0625|| Micromonas micros| 0.03 - 0.125|| Moraxella catarrhalis| 0.002 - ≤0.016|| Morganella morganii| 0.03 - 0.5|| Neisseria meningitidis| 0.03 - 0.016|| Neisseria spp.| 0.002 - 0.03|| Nonsporing gram-positive rods| 0.03 - 8|| Pandoraea apista| 1 - >32|| Pandoraea genomo| ≥32|| Pandoraea pnomenusa| ≥32|| Pantoea agglomerans| 0.12|| Parvimonas micra| 0.047 - 0.38|| Pemphigus mirabilis| 0.06 - 4|| Pemphigus vulgaris| 0.13 - 0.25|| Peptoniphilus asaccharolyticus| ≤0.016 - 0.125|| Peptoniphilus gorbachii | 0.004 - 0.064|| Peptoniphilus harei | 0.004 - 0.032|| Peptoniphilus ivorii | 0.002 - 0.016|| Peptoniphilus lacrimalis | 0.002 - 0.016|| Peptoniphilus octavius | ≥0.094|| Peptostreptococcus anaerobius| 0.023 - 8|| Peptostreptococcus magnus| ≤0.03 - 4|| Peptostreptococcus micros| ≤0.03 - 4|| Peptostreptococcus spp.| ≤0.004 - 4|| Pneumococci| 0.002 - 16|| Porphyromonas asaccharolytica| ≤0.016 - 0.12|| Porphyromonas endodontalis | 0.06 - 0.12|| Porphyromonas gingivalis| ≤0.016 - 1|| Porphyromonas levii | ≤0.016|| Porphyromonas spp.| 0.031 - 8|| Prevotella bivia| 0.03 - 2|| Prevotella buccae| 0.06 - 1|| Prevotella corporis | ≤0.016 - 0.06|| Prevotella denticola| ≤0.016 - 0.06|| Prevotella disiens| 0.03 - 2|| Prevotella intermedia| ≤0.016 - 2|| Prevotella loescheii| 0.06 - 0.12|| Prevotella melaninogenica| ≤0.016 - 0.25|| Prevotella melaninogenicus | 0.06 - 1|| Prevotella nigrescens| ≤0.016 - 2|| Prevotella oralis| 0.06 - 1|| Prevotella oris| 0.03 - 0.25|| Prevotella spp.| 0.03 - 1|| Propionibacterium acnes| 0.06 - 0.5|| Proteus mirabilis| 0.031 - 0.5|| Proteus rettgeri| ≤0.12|| Proteus spp.| ≤0.06 - 0.5|| Proteus vulgaris| 0.03 - 0.25|| Providencia rettgeri| 0.032 - >32|| Providencia spp.| ≤0.06 - >32|| Providencia stuartii | 0.25 - 2|| Pseudomonas aeruginosa| 0.008 - >128|| Pseudomonas spp.| 0.15 - 16|| Ralstonia pickettii (PIC-1)| ≥2|| Ruminococcus gnavus| ≥0.125|| Salmonella spp.| 0.12|| Salmonella typhimurium| ≥0.05|| Serratia marcescens| ≤0.016 - >128|| Staphylococci| 0.015 - >128|| Staphylococcus aureus| ≤0.06 - 64|| Staphylococcus epidermidis| 0.06 - 64|| Stenotrophomonas maltophilia| 0.25 - 128|| Streptococci| ≤0.016 - 0.12|| Streptococcus agalactiae| 0.016 - 32|| Streptococcus faecalis| 31.3 - ≥500|| Streptococcus pneumonia| 0.008 - 2|| Streptococcus pyogenes| ≤0.004 - 0.008|| Sutterella wadsworthensis| 0.03 - >32|| Veillonella parvula| ≤0.03 - 0.5|| Veillonella spp.| ≤0.004 - 0.5||