Pyrantel (+)-tartrate salt is an anthelmintic (anti-protozoal) that was first desribed in 1965 by Pfizer. It is effective against intestinal nematodes (roundworm, threadworm, and hookworm, nodular worm). The compound is soluble in DMSO.
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|Mechanism of Action|| |
Pyrantel (+)-tartrate salt is a nicotinic receptor agonist. It can activate nACh receptors on the body wall muscle of nematodes, causing muscle paralysis.
|General Applications|| |
Pyrantel (+)-tartrate salt is used to study allosteric modulation of the neuronal nicotinic acetylcholine receptors (nAChRs).
|Eukaryotic Cell Culture Applications|| |
Pyrantel tartrate was evaluated during in vitro culture of horse dermal cell culture in which merozoites from Sarcocystic neurona were growing,the causal agent of protozoal yeloencephalitis, a neurologic disease of horses. Merozoites were exposed to a range of concentrations then plated onto dermal cell cultures. Authors found that pyrantel tartrate has activity against emerozoites in vitro (Kruttlin et al, 2001).
|Molecular Formula||C11H14N2S · C4H6O6|
Aubry ML, Cowell P, Davey MJ and Shevde S (1970) Aspects of the pharmacology of a new anthelmintic: pyrantel. Br. J. Harmacol 38(2):332-344 PMID 5417856
Kruttlin EA (2001) The effects of pyrantel tartrate on Sarcocystis neurona merozoite viability.Vet Ther. 2(3):268-276 PMID 19746670