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Lepimectin A4

Lepimectin A4 is a the major analog of a complex of semi-synthetic milbemycins synthesised from 15-hydroxy-5-ketomilbemycin A3/A4 by coupling to methoxyiminophenylacetic acid and then reducing with sodium borohydride.Commercially, Lepimectin is a mixture...

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Leoidin

Leoidin is a metabolite of the lichen, Lecanora gangleoides, first published in 1986 and recently reported as an inhibitor ofprotein synthesis in Pseudomonas aeruginosa. Leoidin is bacteriostatic, targeting PheRS. Leoidin is a weak inhibitor of human...

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Methyl Betulinate

Methyl Betulinate is the methyl ester of Betulinic Acid, a pentacyclic lupane terpene isolated as a constituent of various tree species, including birch. In Australia, Methyl Betulinate was isolated from Akania bidwillii (syn. Akania lucens) by Ritchie...

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Multiflorenol

Multiflorenol is a triterpenoid found in the geranium family and other flowering plants, first isolated and the structure elucidated by Khastgir and Sengupta in 1961. Multiflorenol was subsequently isolated by Ritchie and Taylor from the Australian...

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Monocrotaline

Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid derived from members of the Crotolaria species, longknown to cause poisoining among livestock. Monocrotaline causes pulmonary artery hypertension, right ventricularhypertrophy, and...

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Mer-NF5003E

Mer-NF5003E is a sesquiterpenoid mycotoxin isolated from Stachybotrys strains, first published in 1994 as an avianmyeloblastosis virus (AMV) protease inhibitor. Mer-NF5003E is inactive against HIV due to host cell toxicity. An analogue, MerNF5003B has...

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Mer-NF5003F

Mer-NF5003F is a sesquiterpenoid mycotoxin isolated from Stachybotrys strains, first published in 1994 as an avianmyeloblastosis virus (AMV) protease inhibitor. Mer-NF5003F is inactive against HIV due to host cell toxicity. An analog, MerNF5003B has been...

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Methylspinazarin

Methylspinazarin is a rare naphthoquinone pigment produced by a strain of Streptomyces filipinensis, isolated by Nagatsu and colleagues at Ochanomizu University, Japan in 1973. Methylspinazarin inhibits catechol-O-methyl transferase (COMT) and exhibits a...

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Monomethylsulochrin

Monomethylsulochrin is a benzophenone isolated from Aspergillus fumigatus by Turner, ICI Ltd in 1965. Monomethylsulochrin inhibits eosinophil degranulation. Its dimethyl analogue, sulochrin, inhibits VEGF leading to inhibition of capillary-like tube...

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Manumycin A

Manumycin A was isolated by Zeeck and colleagues at the University of Gottingen, Germany published in 1987. Manumycin A is a potent and selective inhibitor of Ras farnesyl transferase. Manumycin A induces apoptosis and inhibits angiogenesis, and has...

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Norstictic Acid

Norstictic acid was first reported in 1934 as a metabolite produced by the lichen, Lobaria pulmonaria, along with two relatedcompounds. Norstictic acid has antioxidant, antimicrobial and antitumor activities. Norstictic acid treatment...

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Novobiocic Acid

Novobiocic Acid is a member of the novobiocin aminocoumarin antibiotic family. Novobiocic Acid is a key intermediate in the biosynthesis of novobiocin and an important acid degradation product. While novobiocic Acid exhibits little antibacterial...

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