Vaborbactam is a non-β-lactam β-lactamase inhibitor. It is synthetic biochemical based on a a cyclic boronic acid pharmacophore. It was discovered by Rempex Pharmaceuticals, a subsidiary of The Medicines Company. It can increase the potency of...
Ozenoxacin is a quinolone antibiotic with bacterididal activity against Staphylococcus aureus and Streptococcus pyogenes, the causal agents of impetigo. Ozenoxacin also has activity against some bacteria that are resistant to fluoroquinolones. The...
Zidebactam is a non-β-lactam antibiotic that is categorized as a diabicyclooctane (DBO). It is a penicillin-binding protein 2 (PBP2) inhibitor with a high affinity for PBP2 in Gram-negative bacteria. When used in combination with cefepime, it can...
Trovafloxacin Mesylate is a broad-spectrum fluoroquinolone antibiotic. It was developed for immunology research (Pfizer). It can inhibit both Gram-positive and Gram-negative bacteria, and anaerobic organisms. The compound inhibits activity of DNA gyrase...
Ravuconazole is a triazole antifungal, a 1-butyl-1H-1,2,4- triazole. The compound has a broad-spectrum antifungal activity, and is active against molds and yeast. It has a spectrum similar to voriconazole. It inhibits cytochrome P450...
Efinaconazole is a triazole antifungal and 14α-demethylase inhibitor. The compound was synthesized as an azoleamine derivative (Kaken Phermaceutical Co). The fungal lanosterol 14α-demethylase is involved in the conversion of lanosterol to...
Geldanamycin ReadyMadeTM solution is provided as a sterile-filtered solution of Geldanamycin formulated in DMSO at a concentration of 1 mg/ml. It has been filter-sterilized using a 0.22 μm filter. Geldanamycin is a 1,4-benzoquinone ansamycin...
Amicoumacin B is a complex antibiotic and isocoumarin produced by Bacillus subtilis. This natural product, a fungal metabolite, is a quorum-sensing inhibitor with activity against Chromobacterium violaceum. It reduces the expression of C. violaceum...
Lefamulin Acetate is a pleuromutilin antibiotic, a group originally isolated from basidiomycetes and developed in the 1950s. Lefamulin was introduced by Nabriva Therapeutics and approved for use in US in 2019. In fact, it was the first pleuromutilin to...
Fluvoxamine Maleate is a selective neuronal serotonin reuptake inhibitor with a 100-fold affinity for the serotonin transporter over the norepinephrine transporter. It is an aralkylketone-derivative agent developed by Solvay, Belgium. It inhibits many...
Nafamostat Mesylate is a synthetic serine protease inhibitor, inhibiting a number of Lys/Arg-specifc serine proteinases. It is a tryptase inhibitor. It is an anticoagulant. proventing the proteolysis of fibrinogen into fibrin. The compound has...
Fumitremorgin B is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Fumitremorgin B is active against a range of phytopathogenic fungi including Botrytis cinerea, Alternaria solani and alternata at 6.25 µg/mL. Fumitremorgen B has potent...