Antitumor

Bafilomycin C1

Bafilomycin C1 is a member of a potent family of macrocyclic lactones. Bafilomycin C1 is broadly active against bacteria, fungi, insects, nematodes and cestodes. Bafilomycin C1 has attracted interest as a potential agent for treating osteoporosis. The...

View Details

Bafilomycin D

Bafilomycin D is a member of a potent family of macrocyclic lactones. Bafilomycin D contains the ring-opened side chain and is a much more stable analogue of bafilomycin A1. Limited availability has restricted a more in depth investigation of this...

View Details

Bestatin

Bestatin is 'pseudo'-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin also exhibits antitumor activity and has been investigated in clinical trials...

View Details

Bithionol

Bithionol is an anti-parasitic drug and has recently been found to have anti-ovarian cancer properties. In one study, bithionol inhibited all tested ovarian cancer cell lines with IC50 values from 19 µM - 60 µM.Mechanism of ActionThe mechanism of action...

View Details

Bleomycin

Bleomycin is a complex of 11 glycopeptide antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components are Bleomycin A2 and Bleomycin B2, which typically represent >90% of the total weight. Bleomycin has anti-cancer...

View Details

Bleomycin A5 Hydrochloride

Bleomycin A5 Hydrochloride is part of the Bleomycin complex.  It is an anti-neoplastic glycoprotein antibiotic used in cancer research.  The Bleomycins were originally isolated for their broad spectrum antibacterial activity.We also offer:...

View Details

Borrelidin

Borrelidin is an unusual nitrile-containing metabolite isolated from Streptomyces. Borrelidin is an important lead for antimalarial discovery, displaying activity against drug-resistant Plasmodia.Borrelidin is soluble in ethanol, methanol, DMF and...

View Details

Butyrolactone I

Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for...

View Details

Butyrolactone V

Butyrolactone V is a saturated dibenzylbutyrolactone lignan isolated from a strain of Aspergillus by Lin and collaborators,Xiamen University, China in 2009. Butyrolactone V is moderately active against the parasites, Plasmodium falciparum,Leishmania...

View Details

Byssochlamic Acid

Byssochlamic Acid is a nonadride mycotoxin first isolated from Byssochlamiys fulva by Raistrick and Smith at the Univeristy of London, UK in 1933. Byssochlamic Acid is closely related to the mycotoxins rubratoxin B, produced by Penicillium rubrum, and...

View Details

Calphostin C

Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides and inhibits cell proliferation and induces apoptosis in vitro.Calphostin C is soluble in ethanol, methanol, DMF and DMSO.Mechanism of...

View Details

Camptothecin (Camptotheca acuminata)

Camptothecin is an alkaloid topoisomerase l (topo l) inhibitor with anticancer properties. Camptothecin is isolated from Camptotheca acuminata, a deciduous tree.This product is considered a dangerous good. Quantities above 1 g may be subject to...

View Details