Chemotherapeutics

Oligomycin D

Oligomycin D (Rutamycin) is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes.  Oligomycins exhibit apoptotic...

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Ophiobolin A

Ophiobolin A is the dominant member of a class of phytotoxic metabolites produced by plant pathogenic fungi.Ophiobolin A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.Mechanism of ActionOphiobolin A acts by inhibiting calmodulin...

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Ophiobolin B

Ophiobolin B is a minor member of a class of phytotoxic metabolites produced by Bipolaris and other genera of plant pathogenic fungi.Ophiobolin B is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.Mechanism of ActionOphiobolin B acts by...

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Salinomycin Sodium

Salinomycin Sodium (syn: Coxistal, Coxistac) is the sodium salt of Salinomycin, a carboxylic polyether ionophore isolated from Streptomyces albus that has been widely used as an agricultural antibiotic to prevent coccidiosis in poultry. Salinomycin...

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Bleomycin Sulfate, USP

Bleomycin Sulfate is a chemotherapeutic agent commonly used for Hodgkin’s lymphoma. Bleomycin is a mixture of Bleomycin A2 and Bleomycin B2. The approximate composition of A2:B2 is 2:1. The compound is water soluble. We also offer: Bleomycin...

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Salinomycin

Salinomycin (syn: Coxistal, Coxistac) is a carboxylic polyether ionophore isolated from Streptomyces albus that has been widely used as an agricultural antibiotic to prevent coccidiosis in poultry. Salinomycin was first isolated in 1974 by the...

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Fusarisetin A

Fusarisetin is an unusual pentacyclic metabolite related to equisetin and isolated from a Fusarium. Fusarisetin was identified from a natural product screen using a three-dimensional matrigel-induced bioassay to study acinar morphogenesis. Fusarisetin is...

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1,10-Phenanthroline Hydrochloride Monohydrate

1,10-Phenanthroline Hydrochloride Monohydrate is a heterocyclic compound with antimycotic and anticancer properties.  It is used as an analytical reagent for colorimetric determination of iron.  The compound an inhibit metallopeptidases,...

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Norfloxacin

Norfloxacin is a first-generation synthetic fluoroquinolone antibiotic. Mechanism of Action Norfloxacin indirectly inhibits DNA gyrase by binding to nearby DNA substrate. DNA gyrase is an essential DNA replication enzyme which reduces DNA strain...

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Miconazole

Miconazole is an imidazole antimycotic compound patented in 1968 by Janssen Pharmaceutica.  It inhibits ergosterol synthesis, and a variety of cytochrome P450 enzymes.   It can act as a chemopreventive agent in a mammary cancer cell model...

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7-Oxostaurosporine

7-Oxostaurosporine is the oxidised and highly fluorescent analogue of UCN-01 and UCN-02. 7-Oxostaurosporine is a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. 7-Oxostaurosporine possesses comparable...

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Mitomycin C

Mitomycin C is a bacteriocidal methylazirinopyrroloindoledione antineoplastic antibiotic isolated from Streptomyces spp.  Mitomycin C can be used as an inhibitor for cell-free protein biosynthesis research. In addition, Mitomycin C is an efficient...

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