Sitafloxacin sesquihydrate is a broad-spectrum fluoroquinoline antibiotic that is particularly active against gram-positive bacteria such as a pneumococci.
|Mechanism of Action||Sitafloxacin has been shown to have a dual targeted mechanism of action. Other antibacterial quinolones target DNA gyrase or topoisomerase IV, but sitafloxacin targets both at a very similar rate. This double-target approach lowers the possibility of resistant strains.|
|Molecular Formula||C19H18ClF2N3O3• 1.5H2O|
|References||Onodera, Y., Uchida, Y., Tanaka, M., & Sato, K. (1999). Dual inhibitory activity of sitafloxacin (DU-6859a) against DNA gyrase and topoisomeraseIV of Streptococcus pneumoniae. Journal Of Antimicrobial Chemotherapy, 44(4), 533-536. http://dx.doi.org/10.1093/jac/44.4.533|