K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumor activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).
K252A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
K252A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
| Molecular Formula | C26H19N3O5 |
| References | K-252a, a potent inhibitor of protein kinase C from microbial origin. Kase H. et al. , J. Antibiot. 1986, 39, 1059. The structures of the novel protein kinase C inhibitors K-252a, b, c and d. Yasuzawa T. et al. , J. Antibiot. 1986, 39, 1072. |