2-Naphthoxyacetic Acid (BNOA) is a synthetic auxin, a plant growth regulator used for control of preharvest fruit drop and root proliferation promotion. The compound inhibits auxin influx, and it can be used to regulate growth of many crop plants. It was first mentioned in 1938 by Irvine.
|Mechanism of Action||
2-Naphthoxyacetic Acid is linked to the dynamics of the plasma membrane, where it inhibits auxin influx.
|Plant Biology Applications||2-Naphthoxyacetic acid is used to regulate growth of fruit crops including tomatoes, apple, grape, and strawberries.
2-Naphthoxyacetic acid has been used to induce somatic embryogenesis in grapevine (Vitis vinifera) from stigma and style explants and somatic embryogenesis was induced 3-7 months after culture initiation (Carimi et al, 2005). It can also promote seed germination and early flowering in tomatoes (Lycopersicon esculentum) (Singh et al, 2003).
|Insect Biology||2-Naphthoxyacetic Acid was used in the Somatic Mutation And Recombination Test (SMART) in Drosophila wings and results showed that the compound is not mutagenic or recombinogenic in the wing cells of Drosophila (Karadeniz et al, 2011).|
|Cancer Research Applications||2-Naphthoxyacetic acid was used in MTT and trypan-blue exclusion assays to review the proliferation and viability of human immortalized embryonic kidney HEK293 cells at the early stage of carcinogenesis. The compound did not affect the proliferation rate of HEK293 cells but induced cell death when used at high concentrations (Karadeniz et al, 2011).|
Carimi et al (2005) Somatic embryogenesis from stigmas and styles of grapevine. In Vitro Cell. Dev. Biol. -Plant. 41:249-252
Karadeniz A, Kaya B, Savas B and Topcuoglu SF (2011) Effects of two plant growth regulators, indole-3-acetic acid and β-naphthoxyacetic acid on genotoxicity in Drosophila SMART assay and on proliferation and viability of HEK293 cells from the perspective of carcinogenesis. Toxicol Ind Health 2799:840-848 PMID 21511897
Pulgarín MJA, García Bermejo GLF, Robles SFI, Rodriquez BS (2012) Simultaneous determination of plant growth regulators 1-naphthylacetic acid and 2-naphthoxyacetic acid in fruit and vegetable samples by room temperature phosphorescence. Phytochem Anal. 23(3):214-221 PMID 21805518
Singh B et al (2003) Effects of phytohormones with different methods of application on the growth and yield of tomato (Lycopersicon esculentum Mill.) Prog. Agric. 3:33-35
Zimmerman PW (1941) Growth regulators of plants and formative effects induced with β-naphthoxy compounds. PNAS 27(8):381-388