Avenaciolide, a bicyclic bis-butyrolactone, was isolated from Aspergillus avenaceus in 1963 as an antifungal agent. Avenaciolide inhibits glutamate transport and is also thought to act as an atypical ionophore.
Avenaciolide is soluble in ethanol, methanol, DMF or DMSO.
Avenaciolide is soluble in ethanol, methanol, DMF or DMSO.
| Mechanism of Action | Avenaciolide inhibits glutamate transport and is also thought to act as an atypical ionophore. |
| References | Avenaciolide, an antifungal lactone from Aspergillus avenaceus. Brookes D. et al. J. Chem. Soc. 1963, 5385. Avenaciolide: a specific inhibitor of glutamate transport in rat liver mitochondria. McGivan J.D. & Chappell J.B. Biochem. J. 1970, 116, 37P. Ionophoric actions of avenaciolide on mitochondrial cations. Harris E.J. & Wimhurst J.M. Arch. Biochem. Biophys. 1974, 162, 426. |