Brefeldin A ReadyMadeTM Solution (BFA) is provided as a sterile-filtered solution of Brefeldin A formulated in DMSO at a concentration of 10 mg/ml. It has been filter-sterilized using a 0.22 μm filter. Brefeldin A is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. It is a bioactive small molecule which is an activator of the sphingomyelin cycle. Brefeldin A may be used to study protein and lipid transport between Golgi complex and the cell surface.
Quantities above 1 gram is considered a Dangerous Good. This quantity may be subject to increased shipping fees. Please consult us for questions.
| Mechanism of Action | Brefeldin A disrupts the structure/function of the Golgi apparatus via inhibition of protein transport from endoplasmic reticulum to the Golgi. The product inhibits the transport of sphingomyelin to the surface of mammalian cells. |
| Spectrum | Neoplastics |
| Cancer Applications | Brefeldin A-mediated apoptosis has been observed in human tumor cells. The ester derivatives of Brefeldin A have anti-cancer properties. |
| Molecular Formula |
C16H24O4 |
