SKU: C214  / 
    CAS Number: 125667-96-1

    Cecropin P1, porcine

    Cecropin P1, porcine is the first of the cecropin family to be isolated from a mammal rather than an insect. It has garnered a lot of interest for its antiviral and broad-spectrum antibacterial activities. It is also active against fungi, and has cytotoxic effects on cancer cell lines.

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    Mechanism of ActionThe antibacterial mode of action for Cecropin P1 is referred to as a "carpet-like" mechanism, in which the charged antimicrobial aligns on the outside of the cell's membrane and destabilizes the packing of the lipid bilayer, eventually causing the membrane to break down.
    Molecular FormulaC147H253N45O43
    ReferencesGazit, E., Miller, I. R., Biggin, P. C., Sansom, M. S., & Shai, Y. (1996). Structure and Orientation of the Mammalian Antibacterial Peptide Cecropin P1 within Phospholipid Membranes. Journal of Molecular Biology, 258(5), 860-870. doi:10.1006/jmbi.1996.0293

    Guo, C., Huang, Y., Cong, P., Liu, X., Chen, Y., & He, Z. (2014). Cecropin P1 inhibits porcine reproductive and respiratory syndrome virus by blocking attachment. BMC Microbiology, 14(1). doi:10.1186/s12866-014-0273-8