SKU: I005  / 
    CAS Number: 74431-23-5; 82009-34-5

    Imipenem w/ Cilastatin (1:1)

    $123.98 - $496.51

    Imipenem w/ Cilastin (1:1) is a 1:1 mixture of Imipenem and Cilastin, a combination originally developed by Merck & Co. in 1985 under the trade name Primaxin.

    Imipenem is a broad-spectrum carbapenem that is effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae, a group of pathogenic microbes resistant to many first line β-lactam antibiotics and certain cephalosporins. Cilastatin is a chemical substance which inhibits dehydropeptidase (DHP1), a human enzyme that degrades Imipenem. 

    This 1:1 mixture of Imipenem w/ Cilastin is soluble in aqueous solution.

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    Mechanism of Action β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many members of the carbapenem subgroup, imipenem is highly resistant to β-lactamase activity.
    Spectrum Imipenem is a broad-spectrum antibiotic targeting a wide range of aerobic and anaerobic Gram-positive and Gram-negative bacteria.
    Microbiology Applications Imipenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
    • Pseudomonas aeruginosa 0.25 µg/mL – 12 µg/mL
    • Bacteroides fragilis 0.008 µg/mL – 1 µg/mL

    For a complete list of Imipenem MIC values, click here.

    Plant Biology Applications Imipenem has been shown to be effective against bacteria from the genus Burkholderia, a well-described plant pathogen. It has also been shown to be effective for sour skin (onions), slippery skin (bulbs), and cavity disease (mushrooms)(Sojanova et al, 2007).
    Molecular Formula C12H17N3O4S • H2O ; C16H26N2O5S
    Assay Imipenem: ≥ 400µg/mg
    Cilastatin: ≥ 400µg/mg
    Imipenem/Cilastatin: 0.95 - 1.05: 1
    References

    Berg PH, Voit EO and White RL (1996)  A pharmacodynamic model for the action of the antibiotic Imipenem on Pseudomonas aeruginosa populations in vitro. Bltn. Mathcal. Biol. 58(5):923-938 

    Chen P et al (2014)  Activity of Imipenem against Klebsiella pneumoniae biofilms in vitro and in vivo. Antimicrob. Agents Chemother. 58(2):1208-1213

    Lyon JA (1985)  Imipenem/cilastatin: The first carbapenem antibiotic. Drug Intell Clin Pharm. 19(12):895‐899

    Pitout JD, Sanders CC, Sanders WE (1997)  Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am J Med 103:51

    Stoyanova M, Pavlina I, Moncheva P and Bogatzevska N (2014)  Biodiversity and incidence of Burkholderia species. Biotechnol. & Biotechnlogic. Equip 21(3):306-310  

    MIC Stenotrophomonas maltophilia (TOT16)| 512 - ?| 659| Stenotrophomonas maltophilia (TOT19)| 256 - ?| 659| Stenotrophomonas maltophilia (TOT43)| 256 - ?| 659| Stenotrophomonas maltophilia (TOT57)| 256 - ?| 659| Stenotrophomonas maltophilia (TOT8)| 512 - ?| 659|