Ketoconazole is an insoluble imidazole antimycotic compound.
This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.
|Mechanism of Action||Ketoconazole increases cell permeability by inhibiting enzymes involved in ergosterol synthesis. The increase of permeability has a toxic effect on the fungi and leads to cell death.|
|Spectrum||Ketoconazole is a broad spectrum antifungal agent targeting a wide variety of fungal cell membranes.|
Rice L.B. and Ghannoum M.A.. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance. Clinical Microbiology Reviews (1999): 501-17.
Van Tyle, J. H. "Ketoconazole. Mechanism of Action, Spectrum of Activity, Pharmacokinetics, Drug Interactions, Adverse Reactions and Therapeutic Use."PubMed (1984): 343-73.