Parvodicin is a family of glycopeptides with potent antibiotic activity, isolated from Actinomadura parvosata. Structurally the parvodicins share a common cyclic peptide core with ristocetin. The analogues within the complex vary in the fatty acid substitution on the aminosugar. Parvodicin complex is a precursor to the synthetic glycopepide, dalbavancin.
Parvodicin complex is soluble in ethanol, methanol, DMF or DMSO. Slightly soluble in water.
| Mechanism of Action | Like other glycopeptides in this class, parvodicin complex inhibits cell wall formation by binding to D-alanine-D-alanine residues. |
| Molecular Formula | C83H88Cl2N8O29 (for C1) |
| References | Parvodicin, a novel glycopeptide from a new species, Actinomadura parvosata: Discovery, taxonomy, activity and structure elucidation. Christensen S.B. et al. J. Antibiot. 1987, 40, 970. Dalbavancin: a novel antimicrobial. Chen A.Y. et al. Int. J. Clin. Pract. 2007, 61, 853. |