SKU: P028  / 
    CAS Number: 113-98-4

    Penicillin G Potassium, USP

    $33.00 - $117.00

    Penicillin G Potassium, USP is a member of the β-lactam antibiotics and was one of the first discovered antibiotics.

    Penicillin G potassium is sparingly soluble in aqueous solution.  

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    Mechanism of Action β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

    Penicillin is targets primarily Gram-positive bacteria including Staphylococcus and Streptococcus species.

    Microbiology Applications Penicillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
    • Streptococcus pneumoniae 0.004 µg/mL – 0.5 µg/mL
    • Streptococcus agalactiae 0.03 µg/mL – 0.06 µg/mL
    • For a representative list of Penicillin MIC values, click here.

    Mycoplasma Media Supplements

    Penicillin can be used as a selective agent in several types of isolation media:

    Mycoplasma Agar - Mycoplasma Supplement G

    Mycoplasma Agar - Mycoplasma Supplement P

    Plant Biology Applications In a study by Windsor et al. (1972), Penicillin G Potassium was shown to control the bacterial plant disease clover club leaf in crimson clover using 100 – 1000 µg/mL.
    Molecular Formula C16H17KN2O4S

    Guzmán, Flavio, MD (2008)  Beta lactam antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Med. Pharmacol.  Pharmacology Corner.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am J Med 1997; 103:51