SKU: R036  / 
    CAS Number: 21884-45-7

    (-)-Rugulosin

    $241.72 - $846.01

    (-)-Rugulosin is the optical isomer of the mycotoxin, (+)-Rugulosin, which was first isolated from Myrothecium verrucaria in 1968. The isomers appear not to be co-produced but both occur widely in several fungal genera. (-)-Rugulosin has been shown to have antiviral properties. (-)-Rugulosin is the less common and less studied isomer, and there are few comparative studies of the relative potency of the isomers.

    (-)-Rugulosin is soluble in ethanol, methanol, DMF and DMSO. 

    References Breen J et al (1955)  Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom.  Biochem. J. 60: 618

    Miller JD et al (2008)  Effect of a Rugulosin-producing endophyte in Picea glauca on Choristoneura fumiferana.  J. Chem. Ecol. 2008, 34, 362

    Nakamura S et al (1971)  Inhibition of phage growth by an antibiotic Rugulosin isolated from Myrothecium verucaria. I. Properties of the anti-phage effect.  Jpn. J. Microbiol. 5:113

    Sankawa U et al (1968)  Further studies on the structures of luteoskyrin, rubroskyrin and Rugulosin. Tet. Lett. 53:5557

    Takeda N et al (1973)  Fungal metabolites. XXXII. Renewed investigation on (-)-flavoskyrin and its analogs. T Tetrahedron 29:3703

    Watts P et al (2003)  Cytotoxicity against insect cells of entomopathogenic fungi of the genera Hypocrella (anamorph Aschersonia): Possible agents for biological control.  Mycological Res. 107:581