Sulfapyridine, USP is a first generation sulfonamide antibiotic and was one of the first compounds used to treat and cure pneumonia. Sulfapyridine has also been found to have anti-inflammatory effects and can be used in immunodeficiency studies.
TOKU-E Company offers two forms of sulfapyridine: sulfapyridine, USP (S065) and sulfapyridine sodium (S106). In aqueous solution, sulfapyridine sodium is freely soluble (667 mg/mL) while sulfapyridine is significantly less soluble (0.29 mg/mL). Both forms have similar potencies and are suitable for microbiology use; however, sulfapyridine sodium is easier to work with in aqueous solution.
|Mechanism of Action||Sulfapyridine inhibits folic acid synthesis by acting as a competitive inhibitor of dihydropteroate synthetase, an enzyme found in the folic acid synthesis pathway.|
|Microbiology Applications||Sulfapyridine can be used to study anti-inflammatory properties.|
Henry, Richard J. "The Mode of Action of Sulfonamides." Bacteriology Reviews (n.d.): 175-84. www.ncbi.gov. Web. 27 Aug. 2012.Paniker, U., and N. Levine. "Dapsone and Sulfapyridine." Dermatologic Clinics 19.1 (2001): 79-86. Nih.gov. Web. 24 Feb. 2014.