Anhydroerythromycin A (Erythromycin impurity D) is an impurity found in Erythromycin and is formed from the acid-catalyzed degradation of Erythromycin A under in vitro and in vivo conditions. It has negligible antibacterial activity but can be used as a reference standard. Anhydroerythromycin A is soluble in chloroform and sparingly soluble in water.
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| Application | Anhydroerythromycin A can be used as a reference standard. Reference standards are well characterized, highly pure compounds that can be used to help identify and/or quantify impurities in pharmaceutical compounds and antimicrobials. |
| Spectrum | Anhydroerythromycin A has negligible antibacterial activity. |
| Solubility | soluble in chloroform and sparingly soluble in water. |
| References | Hassanzadeh A, Helliwell M and Barber J (2006) Determination of the stereochemistry of anhydroerythromycin A, the principal degradation product of the antibiotic Erythromycin A. Org. Biomol. Chem. 4:1014-1019 PMID 16525545 |
