SKU: A138  / 
    CAS Number: 71831-09-9

    Avermectin B1a monosaccharide

    6,200,155.00Rp - 21,635,835.00Rp
    Avermectin B1a monosaccharide
    Avermectin monosaccharide is an acid degradation product produced by selective hydrolysis of the terminal saccharide unit of avermectin. Avermectin monosaccharide is a potent inhibitor of nematode larval development, but is devoid of paralytic activity. Despite the importance of avermectin as an anthelmintic in animal health, there are few published reports of the biological activity or the levels of avermectin monosaccharide in animals or in the environment.

    Avermectin monosaccharide is soluble in ethanol, methanol, DMF and DMSO.  
    Mechanism of ActionAvermectins can modulate gamma-aminobutyric acid (GABA) chloride channels in vertebrate neurons.
    Insect Biology ApplicationsElectrophysiological findings by injection of E. elegans mRNA into Xenopus laevis oocytes indicated that Avermectins act on glutamate-gated chloride channels in nematodes.
    References

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    Pivnichny JV, Shim JK and Zimmerman LA (1983)  Direct determination of avermectins in plasma at nanogram levels by high-performance liquid chromatography. J. Pharm. Sci. 72(12):1447-1450  PMID 6663483