Candicidin is a fungicidal polyene antifungal agent derived from Streptomyces griseus, named for its high activity against the yeast Candida albicans.
| Mechanism of Action | Candicidin alters membrane permeability by binding to ergosterol, a membrane sterol unique to fungi. As a result, an intracellular ion imbalance occurs leading to cell death. |
| Spectrum | Candicidin targets primarily fungi responsible for vulvovaginal candidiasis namely Candida albicans. |
| Molecular Formula | C59H84N2O18 |
| References | Hammond, SM and Kliger BN (1976) Mode of action of the polyene antibiotic Candicidin: Binding factors in the wall of Candida albicans. Antimicrob. Agents Chemother. 9(4):561-568 Waksman SA et al (1965) Candicidin and other polyenic antifungal antibiotics. Bulletin of the World Health Organization 33(2): 219-226 |