Dihydrocyclosporin A is co-metabolite of Cyclosporin A. Dihydrocyclosporin A has no immunosuppressant activity and has found use as a control to determine the role of Cyclosporin A in pharmacology, particularly in the treatment of parasitic infections. Dihydrocyclosporin A is soluble in ethanol, methanol, DMF and DMSO.
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|Eukaryotic Cell Culture Applications||Dihydrocyclosporin A is used as a control to determine the role of Cyclosporin A in pharmacology, particularly in parasitic infection.|
|References||Meier GP et al (1990) Isolation and identification of a novel human metabolite of cyclosporin A: dihydro-CsA M17. Drug Metab Dispos. 18:68 |
Chappell LH et al (1987) Dosage, timing, and route of administration of cyclosporin A and nonimmunosuppressive derivatives of dihydrocyclosporin A and cyclosporin C against Schistosoma mansoni in vivo and in vitro. Antimicrob Agents Chemother. 31:1567
Chappell LH et al (1989) Action of cyclosporin A on the tapeworms Hymenolepis microstoma, H. diminuta and Mesocestoides corti in vivo. Parasitology. 98:291