Dihydrocyclosporin A is co-metabolite of Cyclosporin A. Dihydrocyclosporin A has no immunosuppressant activity and has found use as a control to determine the role of Cyclosporin A in pharmacology, particularly for parasitic infections. Dihydrocyclosporin A is soluble in ethanol, methanol, DMF and DMSO.
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| Eukaryotic Cell Culture Applications | Dihydrocyclosporin A is used as a control to determine the role of Cyclosporin A in pharmacology, particularly in parasitic infection. |
| Molecular Formula | C62H113N11O12 |
| References | Meier GP et al (1990) Isolation and identification of a novel human metabolite of Cyclosporin A: dihydro-CsA M17. Drug Metab Dispos. 18:68 Chappell LH et al (1987) Dosage, timing, and route of administration of Cyclosporin A and nonimmunosuppressive derivatives of dihydrocyclosporin A and Cyclosporin C against Schistosoma mansoni in vivo and in vitro. Antimicrob Agents Chemother. 31:1567 Chappell LH et al (1989) Action of Cyclosporin A on the tapeworms Hymenolepis microstoma, H. diminuta and Mesocestoides corti in vivo. Parasitology. 98:291 |