Furazolidone is a nitrofuran antibiotic and is sparingly soluble in aqueous solution at 40 µg/mL.
|Mechanism of Action||Furazolidone targets bacterial DNA to induce crosslinks which lead to an increased mutation rate or prevents complete DNA replication.|
|Spectrum||Furazolidone is a broad spectrum antibiotic targeting bacteria responsible for gastrointestinal infections.|
|Microbiology Applications||Furazolidone is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include: |
Chatterjee, S. N. "Mechanism of Action of Furazolidone: Inter-strand Cross-linking in DNA & Liquid Holding Recovery of Vibrio Cholerae Cells." Indian Journal of Biochemistry and Biophysics 16.3 (1979): 125-30. www.ncbi.gov. Web. 10 Sept. 2012.
|MIC||Lactobacillus reuteri| 90|| Treponema hyodysenteriae | ≤0.1 - 1.56 || Vibrio harveyi| 12.5|||