Hesperidin is a flavonoid produced by citrus species, first published in 1943. Hesperidin has a broad pharmacological profile, including antihyperlipidemic, cardioprotective, antihypertensive and antidiabetic activities, mainly attributed to antioxidant activity and suppression of pro-inflammatory cytokine production. Hesperidin causes strongly dose-dependent G2/M phase cell cycle arrest. Hesperidin is also neuroprotective.
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Du GY et al (2018) Hesperidin exhibits in vitro and in vivo antitumor effects in human osteosarcoma MG-63 cells and xenograft mice models via inhibition of cell migration and invasion, cell cycle arrest and induction of mitochondrial mediated apoptosis. Oncol. Lett. 6299
Goldstein DH et al (1943) The influence of methyl chalcone of hesperidin on the toxicity of mapharsen in rabbits. Science 98:245
Hajialyani M et al (2019) Hesperidin as a neuroprotective agent: A review of animal and clinical evidence. Molecules 24:E648