Hesperidin is a flavonoid produced by citrus species, first published in 1943. Hesperidin has a broad pharmacological profile, including antihyperlipidemic, cardioprotective, antihypertensive and antidiabetic activities, mainly attributed to antioxidant activity and suppression of pro-inflammatory cytokine production. Hesperidin causes strongly dose-dependent G2/M phase cell cycle arrest. Hesperidin is also neuroprotective.
| Molecular Formula | C28H34O15 |
| References | Amiot MJ et al (2016) Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. Obes. Rev. 17:573 Du GY et al (2018) Hesperidin exhibits in vitro and in vivo antitumor effects in human osteosarcoma MG-63 cells and xenograft mice models via inhibition of cell migration and invasion, cell cycle arrest and induction of mitochondrial mediated apoptosis. Oncol. Lett. 6299 Goldstein DH et al (1943) The influence of methyl chalcone of hesperidin on the toxicity of mapharsen in rabbits. Science 98:245 Hajialyani M et al (2019) Hesperidin as a neuroprotective agent: A review of animal and clinical evidence. Molecules 24:E648 |