Mevastatin (Syn: Compactin) is a statin compound commonly used to combat hypercholesterolemia.
Mevastatin is sparingly soluble in ethanol and DMSO but practically insoluble in water.
| Mechanism of Action | Mevastatin inhibits HMG-CoA reductase, a significant enzyme involved in the cholesterol synthesis pathway. |
| Cancer Applications | Research has shown that Mevastatin have been able to inhibit melanoma cell growth in vitro at high concentrations. |
| Absorbance | UV max: 230, 237 and 246 nm (log ε 4.28, 4.30, 4.11) |
| Optical Rotation | [α]D22 = +283° (c = 0.48 in acetone) |
| References |
Eustace AJ et al (2012) The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and Mevastatin inhibit proliferation and invasion of melanoma cells.BMC Cancer 8(9) |