SKU: M004  / 
    CAS Number: 73573-88-3

    Mevastatin (Compactin)


    Mevastatin is a statin prodrug commonly used to combat hypercholesterolemia. Mevastatin is insoluble in water, and soluble in ethanol and DMSO at 25 mg/mL.

    Mechanism of ActionMevastatin inhibits HMG-CoA reductase, a significant enzyme involved in the cholesterol synthesis pathway.
    Cancer ApplicationsResearch has shown that statin drugs including mevastatin have been able to inhibit melanoma cell growth when high concentrations are used.
    AbsorbanceUV max: 230, 237 and 246 nm (log ε 4.28, 4.30, 4.11)
    Optical Rotation[α]D22 = +283° (c = 0.48 in acetone)

    Eustace, A. J., and et al. "The 3-hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors, Simvastatin, Lovastatin and Mevastatin Inhibit Proliferation and Invasion of Melanoma Cells." BMC Cancer 8.9 (2008): 16 Jan. 2008. Web. 31 Aug. 2012.