Mevastatin is a statin prodrug commonly used to combat hypercholesterolemia. Mevastatin is insoluble in water, and soluble in ethanol and DMSO at 25 mg/mL.
| Mechanism of Action | Mevastatin inhibits HMG-CoA reductase, a significant enzyme involved in the cholesterol synthesis pathway. |
| Cancer Applications | Research has shown that statin drugs including mevastatin have been able to inhibit melanoma cell growth when high concentrations are used. |
| Absorbance | UV max: 230, 237 and 246 nm (log ε 4.28, 4.30, 4.11) |
| Optical Rotation | [α]D22 = +283° (c = 0.48 in acetone) |
| References | Eustace, A. J., and et al. "The 3-hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors, Simvastatin, Lovastatin and Mevastatin Inhibit Proliferation and Invasion of Melanoma Cells." BMC Cancer 8.9 (2008): www.ncbi.gov. 16 Jan. 2008. Web. 31 Aug. 2012. |