SKU: T134  / 
    CAS Number: 70407-20-4

    Territrem B

    $246.96 - $864.36

    Territrem B is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem B is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and the organophospates.

    Molecular Formula C29H34O9

    Cheung J et al (2013) Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. Med. Chem. Lett. 4:1091

    Dowd PF (1992)  Toxicity and anticholinesterase activity of the fungal metabolites territrems to the corn earworm, Helicoverpa zea.  Entomol. Exp. Appl. 65:57

    Jen-Wei Chen J-W (1999)  Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. J. Biol. Chem. 274:34916

    Ling KL (1979)  Territrems, tremorgenic mycotoxins of Aspergillus terreus. Appl. Env. Microbiol. 37:355