Territrem A is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem A is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and theorganophospates.
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Peng F.C. et al (2003) Role of human hepatic cytochrome P-450s in territrem A metabolism. J. Toxicol. Environ. Health A. 11(66):1237