Territrem A is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem A is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and theorganophospates.
| Molecular Formula | C28H30O9 |
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| References | Cheung J et al (2013) Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. Med. Chem. Lett. 4:1091 Dowd PF (1992) Toxicity and anticholinesterase activity of the fungal metabolites territrems to the corn earworm, Helicoverpa zea. Entomol. Exp. Appl. 65:57 Ling KL (1979) Territrems, tremorgenic mycotoxins of Aspergillus terreus. Appl. Env. Microbiol. 37:355 Peng F.C. et al (2003) Role of human hepatic cytochrome P-450s in territrem A metabolism. J. Toxicol. Environ. Health A. 11(66):1237 |
