SKU: T133  / 
    CAS Number: 70407-19-1

    Territrem A

    $246.96 - $864.36

    Territrem A is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem A is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE).  The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and theorganophospates.

    Molecular Formula C28H30O9
     

     

    References

    Cheung J et al (2013) Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. Med. Chem. Lett. 4:1091

    Dowd PF (1992)  Toxicity and anticholinesterase activity of the fungal metabolites territrems to the corn earworm, Helicoverpa zea.  Entomol. Exp. Appl. 65:57

    Ling KL (1979)  Territrems, tremorgenic mycotoxins of Aspergillus terreus. Appl. Env. Microbiol. 37:355

    Peng F.C. et al (2003)  Role of human hepatic cytochrome P-450s in territrem A metabolism. J. Toxicol. Environ. Health A. 11(66):1237