-
Detailed Description
CAS Number: 8064-90-2
Molecular Formula: C14H18N4O3 · 5
C10H11N3O3SMolecular Weight: 1556.71
Mechanism of Action: Co-trimoxazole interferes with bacterial folic acid metabolism by blocking nucleotide biosynthesis. Trimethoprim binds to dihydrofolate reductase (DHFR) which blocks the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF) and gives the compound its antimicrobial effect. Sulfamethoxazole interferes with nucleic acid synthesis by blocking conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net result is to inhibit thymine synthesis which in turn prevents the synthesis of bacterial DNA.
Storage Conditions: -20C
Tariff Code: 3824.99.9297
-
Applications
Spectrum: Co-trimoxazole is broad-spectrum, active against Gram-negative bacteria, Gram-positive bacteria, fungi, parasites, and some mycobacteria. Non-susceptible organisms include Mycobacterium tuberculosis, Treponema pallidum, Pseudomonas aeruginosa and Mycoplasma species.
Microbiology Applications: In vitro activity of Co-trimoxazole was compared with ampicillin, tetracycline, sulfonamide and trimethoprim against 24 Gram-negative and 11 Gram-positive species. Co-trimoxazole is active against major pathogens of infections of the upper and lower respiratory, urinary tract and enteric infections and has a low incidence of resistant organisms.
-
Specifications
Form: Solution
Source: Synthetic; mixture
-
References
References:
Alanio A, Dellière S, Voicu S, Bretagne S and Mégarbane B (2021) The presence of Pneumocystis jirovecii in critically ill patients with COVID-19. J. Infection 82(4):84–123
Bauernfeind A, Hörl G and Przyklenk B (1987) Microbiological perspectives of Co-trimoxazole. Infection 15, S232–S235
Wormser GP, Keusch GT and Heel RC (1982) Co-trimoxazole (Trimethoprim-Sulfamethoxazole). Drug Eval. 24:459-518
Co-trimoxazole ReadyMade™ Solution is provided as a sterile-filtered solution formulated in DMSO at a concentration of 100 mg/ml.
Co-trimoxazole (Syn: Trimethoprim-Sulfamethoxazole) is a combination of two anti-infectives, trimethoprim and sulfamethoxazole, in a ratio of one part trimethoprim to five parts sulfamethoxazole. A syngergistic effect has been demonstrated both in vitro and in animal studies, as they inhibit successive steps in the folate synthesis pathway. Co-trimoxazole belongs to the sulfonamide class and is bactericidal and antiparasitic in nature, useful against bacteria causing respiratory tract infections It also has immunomodulatory and anti-inflammatory properties and may be studied to ameliorate the cytokine storm syndrome associated with severe COVID-19 disease.
CAS Number: 8064-90-2
Molecular Formula: C14H18N4O3 · 5
C10H11N3O3S
Molecular Weight: 1556.71
Mechanism of Action: Co-trimoxazole interferes with bacterial folic acid metabolism by blocking nucleotide biosynthesis. Trimethoprim binds to dihydrofolate reductase (DHFR) which blocks the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF) and gives the compound its antimicrobial effect. Sulfamethoxazole interferes with nucleic acid synthesis by blocking conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net result is to inhibit thymine synthesis which in turn prevents the synthesis of bacterial DNA.
Storage Conditions: -20C
Tariff Code: 3824.99.9297
Spectrum: Co-trimoxazole is broad-spectrum, active against Gram-negative bacteria, Gram-positive bacteria, fungi, parasites, and some mycobacteria. Non-susceptible organisms include Mycobacterium tuberculosis, Treponema pallidum, Pseudomonas aeruginosa and Mycoplasma species.
Microbiology Applications: In vitro activity of Co-trimoxazole was compared with ampicillin, tetracycline, sulfonamide and trimethoprim against 24 Gram-negative and 11 Gram-positive species. Co-trimoxazole is active against major pathogens of infections of the upper and lower respiratory, urinary tract and enteric infections and has a low incidence of resistant organisms.
Form: Solution
Source: Synthetic; mixture
References:
Alanio A, Dellière S, Voicu S, Bretagne S and Mégarbane B (2021) The presence of Pneumocystis jirovecii in critically ill patients with COVID-19. J. Infection 82(4):84–123
Bauernfeind A, Hörl G and Przyklenk B (1987) Microbiological perspectives of Co-trimoxazole. Infection 15, S232–S235
Wormser GP, Keusch GT and Heel RC (1982) Co-trimoxazole (Trimethoprim-Sulfamethoxazole). Drug Eval. 24:459-518
