SKU: C207  / 
    CAS Number: 35825-57-1


    $129.09 - $286.84
    Cryptotanshinone is one of several bioactive tanshinones extracted from the Chinese medicinal herb, Salvia mitiorrhiza. It exhibits a variety of bioactivity including antibacterial, antioxidant and anti-inflammatory effects, but has more recently gained interest for its promise in the field of cancer treatment.

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    Mechanism of ActionCryptotanshinone's antitumor activity comes from its ability to inhibit STAT3 phosphorylation, which downstream inhibits cell growth promoter cyclin D1, and interferes with apoptosis inhibitors survivin and Bcl-xL.
    ReferencesShin, D., Kim, H., Shin, K., Yoon, Y., Kim, S., Han, D., & Kwon, B. (2008) Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells. Cancer Research, 69(1), 193-202. doi:10.1158/0008-5472.CAN-08-2575

    Lee, D., Lee, S., Noh, J., & Hong, S. (1999). Antibacterial Activities of Cryptotanshinone and Dihydrotanshinone I from a Medicinal Herb, Salvia miltiorrhiza Bunge. Bioscience, Biotechnology, and Biochemistry, 63(12), 2236-2239. doi:10.1271/bbb.63.2236