SKU: C207  / 
    CAS Number: 35825-57-1

    Cryptotanshinone

    $76,219.26 - $168,888.72
    Cryptotanshinone is one of several bioactive tanshinones extracted from the Chinese medicinal herb, Salvia mitiorrhiza. It exhibits a variety of bioactivity including antibacterial, antioxidant and anti-inflammatory effects, but has more recently gained interest for its promise in the field of cancer treatment.

    This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. 
    Mechanism of ActionCryptotanshinone's antitumor activity comes from its ability to inhibit STAT3 phosphorylation, which downstream inhibits cell growth promoter cyclin D1, and interferes with apoptosis inhibitors survivin and Bcl-xL.
    ReferencesShin, D., Kim, H., Shin, K., Yoon, Y., Kim, S., Han, D., & Kwon, B. (2008) Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells. Cancer Research, 69(1), 193-202. doi:10.1158/0008-5472.CAN-08-2575

    Lee, D., Lee, S., Noh, J., & Hong, S. (1999). Antibacterial Activities of Cryptotanshinone and Dihydrotanshinone I from a Medicinal Herb, Salvia miltiorrhiza Bunge. Bioscience, Biotechnology, and Biochemistry, 63(12), 2236-2239. doi:10.1271/bbb.63.2236