SKU: G062  / 
    CAS Number: 66803-19-8

    Gentamicin C2b sulfate, EvoPure®


    Gentamicin C2b sulfate, EvoPure® is one of several components in the Gentamicin C complex, along with Gentamixin C1 and C1a, and the complex comprises approximately 80% of Gentamicin and exhibits the highest antimicrobial activity. The higher antimicrobial activity of the group C Gentamicins is thought to arise from the lack of hydroxy groups on the 3’ and 4’ positions of the purpurosamine (2-amino-hexose) fragments.

    Mechanism of ActionAminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.
    SpectrumGentamicin is a broad-spectrum antibiotic; however, it is mostly used to treat infections caused by Gram-negative bacteria. It is effective against several strains of Mycoplasma.
    Microbiology ApplicationsGentamicin EvoPure® compounds can be used to study effects of individual Gentamicin components on various bacterial strains.
    Molecular Formula

    C20H41N5O· xH2SO4 (lot specific)

    ReferencesDavis, BD (1987) Mechanism of Bactericidal Action of Aminoglycosides. Microbiol. Rev. 51(3): 341-350 PMID 3312985

    Stypulkowska K, Blazewicz A, Fijalek Z, Sarna K.(2010) Determination of gentamicin sulphate composition and related substances in pharmaceutical preparations by LC with charged aerosol detection. Chromatograph. 72(11-12):1225-1229 PMID 21212825

    Vydrin, AF (2003) Component composition of gentamicin sulfate preparations. Pharma. Chem. J 37(8): 448-449

    Weinstein, MJ, Wagman GH, Oden EM and Marquez JA (1967) Biological activity of the antibiotic components of the gentamicin complex. J. Bacteriol. 94(3):789-790 PMID 4962848