SKU: G062  / 
    CAS Number: 66803-19-8

    Gentamicin C2b Sulfate, EvoPure®


    Gentamicin C2b Sulfate, EvoPure® is one of several components in the Gentamicin C complex, along with Gentamicin C1 and C1a, the group C complex comprising ~ 80% of Gentamicin and has the highest degree of antimicrobial activity. The higher antimicrobial activity of the group C Gentamicins is thought to arise from the lack of hydroxy groups on the 3’ and 4’ positions of the purpurosamine (2-amino-hexose) fragments.

    EvoPure® products have been fully characterized by spectral analysis and are shipped with a comprehensive certificate of analysis containing lot-specific HPLC, MS, HNMR, and FTIR data.

    We also offer:

    • Gentamicin Sulfate, USP (G006)
    • Gentamicin Sulfate EP (G007)
    • Gentamicin Sulfate Solution (50 mg/ml in Water), (G046)
    • Gentamicin A Sulfate (G035)
    • Gentamicin C1 Sulfate, EvoPure® (G031)
    • Gentamicin C1a Sulfate, EvoPure® (G032)
    • Gentamicin C2 Sulfate, EvoPure® (G033)
    • Gentamicin C2a Sulfate, EvoPure® (G034)
    • Gentamicin X2 Sulfate, EvoPure® (G036)
    Mechanism of Action Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.
    Spectrum Gentamicin is a broad-spectrum antibiotic; however, it is mostly used to treat infections caused by Gram-negative bacteria. It is effective against several strains of Mycoplasma.
    Microbiology Applications Gentamicin EvoPure® compounds can be used to study effects of individual Gentamicin components on various bacterial strains.
    Molecular Formula

    C20H41N5O· xH2SO4 (lot specific)

    References Davis, BD (1987) Mechanism of bactericidal action of aminoglycosides. Microbiol. Rev. 51(3): 341-350 PMID 3312985

    Stypulkowska K, Blazewicz A, Fijalek Z, Sarna K.(2010) Determination of Gentamicin Sulphate composition and related substances in pharmaceutical preparations by LC with charged aerosol detection. Chromatograph. 72(11-12):1225-1229 PMID 21212825

    Vydrin, AF (2003) Component composition of Gentamicin Sulfate preparations. Pharma. Chem. J 37(8): 448-449

    Weinstein, MJ, Wagman GH, Oden EM and Marquez JA (1967) Biological activity of the antibiotic components of the Gentamicin complex. J. Bacteriol. 94(3):789-790 PMID 4962848