Gentamicin C2b Sulfate, EvoPure® is one of several components in the Gentamicin C complex, along with Gentamicin C1 and C1a, the group C complex comprising ~ 80% of Gentamicin and has the highest degree of antimicrobial activity. The higher antimicrobial activity of the group C Gentamicins is thought to arise from the lack of hydroxy groups on the 3’ and 4’ positions of the purpurosamine (2-amino-hexose) fragments.
EvoPure® products have been fully characterized by spectral analysis and are shipped with a comprehensive certificate of analysis containing lot-specific HPLC, MS, HNMR, and FTIR data.
We also offer:
- Gentamicin Sulfate, USP (G006)
- Gentamicin Sulfate EP (G007)
- Gentamicin Sulfate Solution (50 mg/ml in Water), (G046)
- Gentamicin A Sulfate (G035)
- Gentamicin C1 Sulfate, EvoPure® (G031)
- Gentamicin C1a Sulfate, EvoPure® (G032)
- Gentamicin C2 Sulfate, EvoPure® (G033)
- Gentamicin C2a Sulfate, EvoPure® (G034)
- Gentamicin X2 Sulfate, EvoPure® (G036)
| Mechanism of Action | Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein. |
| Spectrum | Gentamicin is a broad-spectrum antibiotic; however, it is mostly used to treat infections caused by Gram-negative bacteria. It is effective against several strains of Mycoplasma. |
| Microbiology Applications | Gentamicin EvoPure® compounds can be used to study effects of individual Gentamicin components on various bacterial strains. |
| Molecular Formula |
C20H41N5O7 · xH2SO4 (lot specific) |
| References | Davis, BD (1987) Mechanism of bactericidal action of aminoglycosides. Microbiol. Rev. 51(3): 341-350 PMID 3312985 Stypulkowska K, Blazewicz A, Fijalek Z, Sarna K.(2010) Determination of Gentamicin Sulphate composition and related substances in pharmaceutical preparations by LC with charged aerosol detection. Chromatograph. 72(11-12):1225-1229 PMID 21212825 Vydrin, AF (2003) Component composition of Gentamicin Sulfate preparations. Pharma. Chem. J 37(8): 448-449 Weinstein, MJ, Wagman GH, Oden EM and Marquez JA (1967) Biological activity of the antibiotic components of the Gentamicin complex. J. Bacteriol. 94(3):789-790 PMID 4962848 |
