Ivermectin B1a (dihydroavermectin B1a) is the major component (>80%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectins and milbemycins are also potent insecticides. The individual 25-sec-butyl (B1a) and 25-iso-propyl (B1b) components of ivermectin have received little separate study.
Ivermectin B1a is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Ivermectin B1a is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| References | Ivermectin, a new broad-spectrum antiparasitic agent. Chabala J.C. et al. J. Med. Chem. 1980, 23, 1134. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. Wolstenholme A.J & Rogers A.T. Parasitology, 2005, 131, S85. Avermectin/milbemycin resistance in trichostrongylid nematodes. Gill J.H. & Lacey E. Int J. Parasitol. 1998, 28, 863. Ivermectin: a potent new antiparasitic agent. Campbell W.C. et al. , Science, 1983, 221, 823. |
