SKU: A138  / 
    CAS Number: 71831-09-9

    Avermectin B1a monosaccharide

    $266.16 - $931.59
    Avermectin monosaccharide is an acid degradation product produced by selective hydrolysis of the terminal saccharide unit of avermectin. Avermectin monosaccharide is a potent inhibitor of nematode larval development, but is devoid of paralytic activity. Despite the importance of avermectin as an anthelmintic in animal health, there are few published reports of the biological activity or the levels of avermectin monosaccharide in animals or in the environment.

    Avermectin monosaccharide is soluble in ethanol, methanol, DMF and DMSO.  
    Mechanism of ActionAvermectins can modulate gamma-aminobutyric acid (GABA) chloride channels in vertebrate neurons.
    Insect Biology ApplicationsElectrophysiological findings by injection of E. elegans mRNA into Xenopus laevis oocytes indicated that Avermectins act on glutamate-gated chloride channels in nematodes.
    References

    Blizzard T, Fisher MH, Mrozik H, Shih TL (1990) Avermectins and Milbemycins. In: Lukacs G, Ohno M. (eds) Recent Progress in the Chemical Synthesis of Antibiotics. Springer, Berlin, Heidelberg

    Chabala J.C. et al. (1980)  Ivermectin, a new broad-spectrum antiparasitic agent. J. Med. Chem. 23:1134

    Chen TS, Inamine ES (1989)  Studies on the biosynthesis of Avermectins. Arch Biochem Biophys. 270(2):521-5  PMID 2705778

    Egerton JR et al (1979)  Avermectins, new family of potent anthelmintic agents: Efficacy of the B1a component. Antimicrob. Agents Chemother. 15(3):372-378  PMID 464563

    Ikeda H and Omura S (1997)  Avermectin biosynthesis. Chem. Rev. 97(7):2591-2610

    Mrozik H. et al (1982)  Avermectin aglycones. 47:489

    Pivnichny JV, Arison BY, Preiser FA, Shim JSK and Mrozik H (1988)  Base-catalyzed isomerization of avermectins. J. Agric. Food Chem 36(4):826-828

    Pivnichny JV, Shim JK and Zimmerman LA (1983)  Direct determination of avermectins in plasma at nanogram levels by high-performance liquid chromatography. J. Pharm. Sci. 72(12):1447-1450  PMID 6663483