Nourseothricin (Streptothricin) Sulfate is a broad-spectrum Streptothricin antibiotic and peptidyl nucleoside derived from Streptomyces noursei. It is used as a selection agent for genetically modified bacteria, yeast, plants, fungi, and protozoa.
Nourseothricin (Streptothricin) Sulfate is soluble in water.
| Mechanism of Action | Nourseothricin sulfate inhibits protein synthesis by inducing miscoding. |
| Microbiology Applications | Nourseothricin sulfate is often used to select for cells with a mutation in the nat1 gene which encodes the enzyme nourseothricin acetyltransferase which confers resistance to Nourseothricin. It can be used in yeasts, bacteria, protozoa, plant cells, and filamentous fungi. |
| Molecular Formula | C50H92N20O18 • H2SO4 |
| References | Kochupurakkal BS and Iglehart JD (2013). Nourseothricin N-acetyl transferase: A positive selection marker for mammalian cells. PLoS ONE 8(7):e68509 |
