Carbenicillin ReadyMade™ Solution

Carbenicillin ReadyMade^TM solution is provided as a sterile filtered solution of Carbenicillin Disodium formulated in 20~30% ethanol at a concentration of 100 mg/ml. It has been filter-sterilized using a 0.22 μm filter.

Carbenicillin Disodium is a carboxypenicillin antibiotic routinely used for gene selection. The compound interferes with peptidoglycan synthesis, thus it can also be used to study the role of penicillin-sensitive transpeptidases in the formation of cell walls. The carboxycillins are susceptible to degradation by β-lactamase enzymes. Carbenicillin is typically used at a concentration of 50-100 μg/ml.

We also offer:

• Carbenicillin Disodium (C126)
• Carbenicillin Disodium, CulturePure^® (C107)

CAS Number: 4800-94-6

Molecular Formula: C₁₇H₁₆N₂Na₂O₆S

Molecular Weight: 422.36

Mechanism of Action: Carbenicillin interferes with PBP (penicillin binding protein) activity otherwise involved in the final phase of peptidoglycan synthesis. PBPs are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised ultimately leading to cell lysis. Resistance to β-lactams is commonly due to cells containing plasmid-encoded β-lactamases.

Storage Conditions: −20°C

Tariff Code: 2941.10.5000