Anhydroepiophiobolin A is a dehydrated analogue of ophiobolin epimerised at the C6 position. Anhydroepiophiobolin A is the major terminal degradation product of ophiobolin A and is co-produced with other ophiobolins in many Bipolaris species. Prior to 1984, references to "anhydroophiobolin" almost certainly refer to anhydroepiophiobolin A as the epimerisation at C6 was not well recognised. Under controlled degradation conditions both anhydroepiophiobolin A and anhydroophiobolin A are observed, but the latter is a minor component readily epimerised to anhydroepiophiobolin A. Like all ophiobolins, anhydroepiophiobolin A possesses a broad biological profile with antibacterial, antifungal, antitumor, herbicidal and nematocidal activities.
Anhydroepiophiobolin A is soluble in ethanol, methanol, DMF and DMSO.
Anhydroepiophiobolin A is soluble in ethanol, methanol, DMF and DMSO.
| References | Isolation of ophiobolin A and its analogs as inhibitors to photosynthesis. Kim J-M.K. et al. Agric. Biol. Chem. 1984, 48, 803. |