Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. Rebeccamycin displays selective antitumor activity against several cell lines. Analogues of rebeccamycin have been tested in clinical trials for cancer therapy.
Rebeccamycin is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol.
Rebeccamycin is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol.
| Mechanism of Action | Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. |
| Molecular Formula | C27H21Cl2N3O7 |
| References | Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Long B. H., et al. , Curr. Med. Chem. Anticancer Agents, 2002, 2, 255. Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin. Woo M. H., et al. , J. Biol. Chem., 2002, 277, 3813. Production and biological activity of rebeccamycin, a novel antitumor agent. Bush J. A., et al. , J. Antibiot., 1987, 40, 668. |