Steffimycin B is an anthracycline metabolite isolated from a Streptomyces sp. with antibacterial and antineoplastic properties. Crystallographic studies of binding to DNA suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analog was shown to be active against ras oncogene-expressed cells.
Steffimycin B is soluble in ethanol, methanol, DMF and DMSO.
| References |
Reusser F (1975) Steffimycin B, a DNA binding agent. Biochim. Biophys. Acta 383:266 Sriram M et al (1991) Molecular structure of antitumor drug steffimycin and modeling of its binding to DNA. J. Biomol. Struct. Dyn. 9:251 |
