Ascochlorin is an antitumor fungal metabolite with antitumor and antiviral properties.
Ascochlorin is soluble in ethanol, methanol, DMF and DMSO and has limited water solubility.
Ascochlorin is soluble in ethanol, methanol, DMF and DMSO and has limited water solubility.
| Mechanism of Action | Ascochlorin specifically inhibits matrix metalloproteinase-9 (MMP-9) activity through suppression of activator protein-1 (AP-1)-dependent induction of MMP-9 gene expression. Via AP-1 suppression, ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. |
| References | Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. Hong S. et al. J. Biol. Chem. 2005, 280, 25202. Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines. Sakaguchi K. et al. Biochem. Biophys. Res. Commun. 2005, 329, 46. Ascochlorin derivatives as ligands for nuclear hormone receptors. Togashi M. et al. J. Med. Chem. 2003, 46, 4113. |