Acadesine was originally identified as a metabolite of Bacillus species and was shown to accumulate in the culture medium of E. coli under sulphonamide stasis. Acadesine is an adenosine-regulating agent that increases bioavailability of adenosine. Ithas been tested clinically as a cardioprotectant and for hematologic malignancies. Acadesine activates AMP-activated protein kinase and inhibits platelet aggregation, induces p53-dependendent apoptosis in B cells and regulates cellular uptake of glucose, beta-oxidation of fatty acids, protein synthesis, and the biogenesis of GLUT4 and mitochondria.
| Molecular Formula | C9H14N4O5 |
| References |
Chloe P et al (2018) AICAR antiproliferativepropertiesinvolve the AMPK-independent activation of the tumor suppressors LATS 1 and 2. Neoplasia 20:555 Mullane K et al (1993) Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury. Cardiovascular Res. 27:43 Shive W et al (1947) 5(4)-Amino-4(5)imidazolecarboxamide, a precursor of purines. J. Am. Chem. Soc. 69:725
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