SKU: A198  / 
    CAS Number: 2627-69-2

    Acadesine

    $166.93 - $584.26

    Acadesine was originally identified as a metabolite of Bacillus species and was shown to accumulate in the culture medium of E. coli under sulphonamide stasis. Acadesine is an adenosine-regulating agent that increases bioavailability of adenosine. Ithas been tested clinically as a cardioprotectant and for hematologic malignancies. Acadesine activates AMP-activated protein kinase and inhibits platelet aggregation, induces p53-dependendent apoptosis in B cells and regulates cellular uptake of glucose, beta-oxidation of fatty acids, protein synthesis, and the biogenesis of GLUT4 and mitochondria.

    Molecular Formula  C9H14N4O5
    References

    Chloe P et al (2018)  AICAR antiproliferativepropertiesinvolve the AMPK-​independent activation of the tumor suppressors LATS 1 and 2. Neoplasia 20:555

    Mullane K et al (1993)  Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury. Cardiovascular Res. 27:43

    Shive W et al (1947)  5(4)-Amino-4(5)imidazolecarboxamide, a precursor of purines. J. Am. Chem. Soc. 69:725