Acarbose is pseudo-oligosaccharide with a terminal C7-cyclitol patented in 1975 by Bayer. Acarbose is a component of the amylostatin complex produced by species of Actinoplanes and Streptomyces. Acarbose acts as a potent inhibitor of α-glucosidases and saccharases. Acarbose is used in diabetes research (type 2).
Acarbose is soluble in water with partial methanol, ethanol DMF and DMSO solubility.
| References | Chemistry and Biochemistry of Microbial alpha-Glucosidase Inhibitors. Truscheit, E. et al. Angew. Chem. Int. Ed. Engl. 1981, 20, 744. Acarbose. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. Clissold S. P. &: Edwards C. Drugs. 1988, 35, 214. |