SKU: A199  / 
    CAS Number: 510-18-9

    Acetomycin

    $181.00 - $632.50

    Acetomycin, a γ-butyrolactone isolated from Streptomyces ramulosus, was first reported in 1958 by Ettlinger et al. at ETH Zurich. Acetomycin is potently active in vitro against HCT-8 human colon adenocarcinoma cells and L1210 murine leukemia cells. Acetomycin is inactive in vivo giving rise to the design and synthesis of esterase-resistant analogues.

    Molecular Formula  C10H14O5
     

    Ettlinger L et al (1958)  Stoffwechselprodukte von Actinomyceten. 12. Mitteilung. Über die Isolierung und Charakterisierung von Acetomycin. Helv. Chim. Acta 41:216

    Mamber SW et al (1987)  Biological effects of acetomycin. I. Activity against tumor cells in vitro and in vivo. J. Antibiot. 40:73

    Mamber SW et al (1987)  Biological effects of acetomycin. II. Inactivation by esterases in vitro. J. Antibiot. 40:77